Steroids and derivatives
Sigma Organic Chemistry Cellulose Acetate Butyrate | 10EA
Cellulose Acetate Butyrate, 10EA
About This Item:
UNSPSC Code: 12352100
Storage: room temp
Sigma Organic Chemistry 1-Butyl-3-methylimidazolium acetate | 50G | 284049-75-8 | MFCD06798175 | >=96.0% (HPLC)
1-Butyl-3-methylimidazolium acetate | 50G | 284049-75-8 | MFCD06798175 | >=96.0% (HPLC)
Sigma Organic Chemistry (+)-4-Cholesten-3-one | 10G | 601-57-0 | MFCD00003663 | 0.98
(+)-4-Cholesten-3-one | 10G | 601-57-0 | MFCD00003663 | 0.98
Sigma Organic Chemistry (+)-4-Cholesten-3-one | 1G | 601-57-0 | MFCD00003663 | 0.98
(+)-4-Cholesten-3-one | 1G | 601-57-0 | MFCD00003663 | 0.98
Apexbio Technology LLC Prednisone 53-03-2 1g
Prednisone is a synthetic glucocorticoid which functions primarily as an agonist of the glucocorticoid receptor (GR) Upon binding to the GR prednisone induces receptor translocation into the nucleus initiating the regulation of gene expression involved in inflammation immune responses and cellular proliferation Due to its immunosuppressive mechanism prednisone is widely used as an experimental tool in biomedical studies exploring inflammatory diseases autoimmune conditions and immune signaling pathways Structurally prednisone is a corticosteroid derivative characterized by specific modifications that affect its pharmacodynamics and bioavailability In laboratory settings prednisone assists researchers in dissecting glucocorticoid-mediated physiological and molecular events evaluating receptor-ligand interactions and examining downstream signaling mechanisms in various cell-based assays and animal models
Apexbio Technology LLC Medroxyprogesterone acetate 71-58-9 10mM (in 1mL DMSO)
Medroxyprogesterone acetate (MPA) is a synthetic steroidal derivative structurally related to the endogenous hormone progesterone classified as a progestin Acting primarily through binding to progesterone receptors it modulates gene transcription influencing endometrial proliferation and reproductive pathways Additionally MPA exhibits affinity toward glucocorticoid receptors which may contribute to its physiological effects In biomedical research MPA serves as a standard experimental tool to investigate progesterone receptor signaling mechanisms and steroid hormone interactions Furthermore it is widely used in studies focused on reproductive biology contraceptive mechanisms hormone replacement therapy models oncology research involving hormone-responsive tumors and conditions such as endometriosis
Apexbio Technology LLC Dexamethasone acetate 1177-87-3 10mM (in 1mL DMSO)
Dexamethasone acetate a synthetic glucocorticoid acts by binding to glucocorticoid receptors influencing gene transcription to suppress inflammatory and immune responses By modulating cytokine production and inhibiting interleukin (IL) signaling pathways dexamethasone acetate serves as an interleukin receptor modulator Typically applied in research related to inflammation autoimmune diseases and cytokine-mediated cellular events it is extensively utilized in functional assays to understand receptor-ligand interactions signal transduction and therapeutic mechanisms Studies report variable IC50 values depending on cell type and assay conditions with typical IC50 ranges documented from 1-10 nM in receptor binding assays providing a reference concentration range for experimental designs
Apexbio Technology LLC Estradiol 50-28-2 10mM (in 1mL DMSO)
Estradiol is an endogenous steroid hormone involved in the regulation of reproductive biology and cellular physiology through interaction with estrogen receptor (ER) subtypes and Estradiol binding to ER initiates genomic and non-genomic signaling pathways influencing transcription of diverse target genes related to proliferation differentiation and metabolism Estradiol-mediated ER signaling modulates cellular processes including epithelial-mesenchymal transition endothelial function oxidative stress responses and gene expression profiles in various cell lines such as HEK293 and U2OS Additionally estradiol treatment regulates cardiovascular function by inducing mitochondrial superoxide dismutase (SOD2) implicating protective effects in vascular conditions Estradiol exhibits ER subtype selectivity with reported ER and ER binding affinities (IC50) around 0 2-0 5 nM utilized broadly in estrogen signaling research and cardiovascular disease modelling
Sigma Organic Chemistry Palladium(II) acetate | recrystallized | 1G | 3375-31-3 | MFCD00012453
Palladium(II) acetate, recrystallized, 1G
About This Item:
Linear Formula: Pd(OCOCH3)2
Storage: room temp
EINECS Number: 222-164-4
Selleck Chemical LLC Dexamethasone 21-phosphate
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects
Selleck Chemical LLC Fluorometholone
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 5g
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions